CD48 protein (STJP000144)
SPECIFICATIONS
HostCHO cells
ImmunogenProtein contains human CD48 chain (aa 27-220) , propeptide (aa 221-243) is removed
General Information
| Short Description | CD48-protein was developed from cho cells. For use in research applications. |
| Host | CHO cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/ml |
| Purification | Purified by ion-exchange chromatography, hydrophobic interaction chromatography and gel-filtration from serum-free CHO growth media |
| Formulation | PBS pH 7.4 |
| Storage Instruction | Store at-70ยฐC upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles |
Target Information
| Gene Symbol | CD48 |
| Gene ID | 962 |
| Uniprot ID | CD48_HUMAN |
| Immunogen | Protein contains human CD48 chain (aa 27-220) , propeptide (aa 221-243) is removed |
Additional Info
| Tissue Specificity | Widely expressed on all hematopoietic cells. |
| Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. |
| Protein Name | Cd48 AntigenB-Lymphocyte Activation Marker Blast-1Bcm1 Surface AntigenLeukocyte Antigen Mem-102Slam Family Member 2Slamf2Signaling Lymphocytic Activation Molecule 2Tct.1Cd Antigen Cd48 |
| Database Links | Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftSecreted |
| Alternative Protein Names | Cd48 Antigen proteinB-Lymphocyte Activation Marker Blast-1 proteinBcm1 Surface Antigen proteinLeukocyte Antigen Mem-102 proteinSlam Family Member 2 proteinSlamf2 proteinSignaling Lymphocytic Activation Molecule 2 proteinTct.1 proteinCd Antigen Cd48 proteinCD48 proteinBCM1 proteinBLAST1 protein |
Information sourced from Uniprot.org