Host: | CHO cells |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | CD48-protein was developed from cho cells. For use in research applications. |
Formulation: | PBS pH 7.4 |
Purification: | Purified by ion-exchange chromatography, hydrophobic interaction chromatography and gel-filtration from serum-free CHO growth media |
Concentration: | 1 mg/ml |
Storage Instruction: | Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles |
Gene Symbol: | CD48 |
Gene ID: | 962 |
Uniprot ID: | CD48_HUMAN |
Immunogen: | Protein contains human CD48 chain (aa 27-220) , propeptide (aa 221-243) is removed |
Tissue Specificity | Widely expressed on all hematopoietic cells. |
Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. |
Protein Name | Cd48 Antigen B-Lymphocyte Activation Marker Blast-1 Bcm1 Surface Antigen Leukocyte Antigen Mem-102 Slam Family Member 2 Slamf2 Signaling Lymphocytic Activation Molecule 2 Tct.1 Cd Antigen Cd48 |
Database Links | Reactome: R-HSA-202733 |
Cellular Localisation | Cell Membrane Lipid-Anchor Gpi-Anchor Secreted |
Alternative Protein Names | Cd48 Antigen protein B-Lymphocyte Activation Marker Blast-1 protein Bcm1 Surface Antigen protein Leukocyte Antigen Mem-102 protein Slam Family Member 2 protein Slamf2 protein Signaling Lymphocytic Activation Molecule 2 protein Tct.1 protein Cd Antigen Cd48 protein CD48 protein BCM1 protein BLAST1 protein |
Information sourced from Uniprot.org