Biotinylated Human ROR1/NTRKR1 protein (C-His-Avi) {Biotin} (STJP012632)
SPECIFICATIONS
HostMammalian Cells
ConjugationBiotin
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Biotinylated Human ROR1/NTRKR1-C-His-Avi protein was developed from mammalian cells and has a target region of C-His-Avi. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | ROR1 |
| Gene ID | 4919 |
| Uniprot ID | ROR1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln30-Glu403 |
Additional Info
| Function | Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling. |
| Protein Name | Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1Neurotrophic Tyrosine Kinase - Receptor-Related 1 |
| Database Links | Reactome: R-HSA-5140745 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxon |
| Alternative Protein Names | Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1 proteinNeurotrophic Tyrosine Kinase - Receptor-Related 1 proteinROR1 proteinNTRKR1 protein |
Information sourced from Uniprot.org