Biotinylated Human ROR1/NTRKR1 protein (C-His-Avi) {Biotin} (STJP012632)

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STJP012632-100
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Short Description :Biotinylated Human ROR1/NTRKR1-C-His-Avi protein was developed from mammalian cells and has a target region of C-His-Avi. For use in research applications.
Applications:ELISA/WB
Host:Mammalian Cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Biotin
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:< 1 EU/µg as determined by LAL test.
Gene Symbol:ROR1
Gene ID:4919
Uniprot ID:ROR1_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Gln30-Glu403
Function Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling.
Protein Name Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1
Neurotrophic Tyrosine Kinase - Receptor-Related 1
Database Links Reactome: R-HSA-5140745
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Axon
Alternative Protein Names Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1 protein
Neurotrophic Tyrosine Kinase - Receptor-Related 1 protein
ROR1 protein
NTRKR1 protein

Information sourced from Uniprot.org

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