ASIC2 Positive Control for STJ500176 peptide (STJ505574)
SPECIFICATIONS
ImmunogenPurified Protein
General Information
| Short Description | ASIC2 Positive Control for STJ500176 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | WB |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | WB: 1:2, 500-1:5, 000 |
| Formulation | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | ASIC2 |
| Gene ID | 40 |
| Uniprot ID | ASIC2_HUMAN |
| Immunogen | Purified Protein |
| Specificity | This is positive control is recommended for use in combination with ASIC2 antibody STJ500176. |
Additional Info
| Tissue Specificity | Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary. |
| Function | Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. |
| Peptide Name | Acid-Sensing Ion Channel 2Asic2Amiloride-Sensitive Brain Sodium ChannelAmiloride-Sensitive Cation Channel 1 - NeuronalAmiloride-Sensitive Cation Channel Neuronal 1Brain Sodium Channel 1Bnc1Bnac1Mammalian Degenerin HomologMdeg |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLocalized At The Plasma Membrane Of NeuronsIn The Soma And Punctated Peripheral Processes |
| Alternative Peptide Names | Acid-Sensing Ion Channel 2 proteinAsic2 proteinAmiloride-Sensitive Brain Sodium Channel proteinAmiloride-Sensitive Cation Channel 1 - Neuronal proteinAmiloride-Sensitive Cation Channel Neuronal 1 proteinBrain Sodium Channel 1 proteinBnc1 proteinBnac1 proteinMammalian Degenerin Homolog proteinMdeg proteinASIC2 proteinACCN proteinACCN1 proteinBNAC1 proteinMDEG protein |
Information sourced from Uniprot.org