| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | ASIC2 Positive Control for STJ500176 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:2, 500-1:5, 000 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | ASIC2 |
| Gene ID: | 40 |
| Uniprot ID: | ASIC2_HUMAN |
| Specificity: | This is positive control is recommended for use in combination with ASIC2 antibody STJ500176. |
| Immunogen: | Purified Protein |
| Tissue Specificity | Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary. |
| Function | Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. |
| Peptide Name | Acid-Sensing Ion Channel 2 Asic2 Amiloride-Sensitive Brain Sodium Channel Amiloride-Sensitive Cation Channel 1 - Neuronal Amiloride-Sensitive Cation Channel Neuronal 1 Brain Sodium Channel 1 Bnc1 Bnac1 Mammalian Degenerin Homolog Mdeg |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Localized At The Plasma Membrane Of Neurons In The Soma And Punctated Peripheral Processes |
| Alternative Peptide Names | Acid-Sensing Ion Channel 2 protein Asic2 protein Amiloride-Sensitive Brain Sodium Channel protein Amiloride-Sensitive Cation Channel 1 - Neuronal protein Amiloride-Sensitive Cation Channel Neuronal 1 protein Brain Sodium Channel 1 protein Bnc1 protein Bnac1 protein Mammalian Degenerin Homolog protein Mdeg protein ASIC2 protein ACCN protein ACCN1 protein BNAC1 protein MDEG protein |
Information sourced from Uniprot.org