ASIC2 Blocking Peptide for STJ500176 peptide (STJ505573)
SPECIFICATIONS
ImmunogenSynthetic peptide taken within amino acid region 450-512 on human Acid-sensing ion channel 2 protein.
General Information
| Short Description | ASIC2 Blocking Peptide for STJ500176 is synthetically produced from the 450-512 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | ASIC2 |
| Gene ID | 40 |
| Uniprot ID | ASIC2_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 450-512 on human Acid-sensing ion channel 2 protein. |
| Immunogen Region | 450-512 |
| Specificity | This blocking peptide is recommended for use in combination with ASIC2 antibody, STJ500176 |
Additional Info
| Tissue Specificity | Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary. |
| Function | Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. |
| Peptide Name | Acid-Sensing Ion Channel 2Asic2Amiloride-Sensitive Brain Sodium ChannelAmiloride-Sensitive Cation Channel 1 - NeuronalAmiloride-Sensitive Cation Channel Neuronal 1Brain Sodium Channel 1Bnc1Bnac1Mammalian Degenerin HomologMdeg |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLocalized At The Plasma Membrane Of NeuronsIn The Soma And Punctated Peripheral Processes |
| Alternative Peptide Names | Acid-Sensing Ion Channel 2 proteinAsic2 proteinAmiloride-Sensitive Brain Sodium Channel proteinAmiloride-Sensitive Cation Channel 1 - Neuronal proteinAmiloride-Sensitive Cation Channel Neuronal 1 proteinBrain Sodium Channel 1 proteinBnc1 proteinBnac1 proteinMammalian Degenerin Homolog proteinMdeg proteinASIC2 proteinACCN proteinACCN1 proteinBNAC1 proteinMDEG protein |
Information sourced from Uniprot.org