| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZNF207 (1-85) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZNF207 |
| Gene ID: |
7756 |
| Uniprot ID: |
ZN207_HUMAN |
| Immunogen Region: |
1-85 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-85 of human ZNF207 (NP_003448.1). |
| Immunogen Sequence: |
MGRKKKKQLKPWCWYCNRDF DDEKILIQHQKAKHFKCHIC HKKLYTGPGLAIHCMQVHKE TIDAVPNAIPGRTDIELEIY GMEGI |
| Tissue Specificity | Ubiquitous. |
| Function | Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome. |
| Protein Name | Bub3-Interacting And Glebs Motif-Containing Protein Znf207BugzHbugzZinc Finger Protein 207 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreCytoplasmCytoskeletonSpindleLocalizes Primarily To The Nucleus In InterphaseConcentrates At Kinetochores Prior To Nuclear Envelope Breakdown And During Early PrometaphaseAnd Disappears From Kinetochores Upon Microtubule-Binding |
| Alternative Antibody Names | Anti-Bub3-Interacting And Glebs Motif-Containing Protein Znf207 antibodyAnti-Bugz antibodyAnti-Hbugz antibodyAnti-Zinc Finger Protein 207 antibodyAnti-ZNF207 antibodyAnti-BUGZ antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
