Anti-ZNF207 antibody (1-85) (STJ11103208)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ZNF207 (1-85) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZNF207 |
| Gene ID | 7756 |
| Uniprot ID | ZN207_HUMAN |
| Immunogen Region | 1-85 |
| Immunogen Sequence | MGRKKKKQLKPWCWYCNRDF DDEKILIQHQKAKHFKCHIC HKKLYTGPGLAIHCMQVHKE TIDAVPNAIPGRTDIELEIY GMEGI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-85 of human ZNF207 (NP_003448.1). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome. |
| Protein Name | Bub3-Interacting And Glebs Motif-Containing Protein Znf207BugzHbugzZinc Finger Protein 207 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreCytoplasmCytoskeletonSpindleLocalizes Primarily To The Nucleus In InterphaseConcentrates At Kinetochores Prior To Nuclear Envelope Breakdown And During Early PrometaphaseAnd Disappears From Kinetochores Upon Microtubule-Binding |
| Alternative Antibody Names | Anti-Bub3-Interacting And Glebs Motif-Containing Protein Znf207 antibodyAnti-Bugz antibodyAnti-Hbugz antibodyAnti-Zinc Finger Protein 207 antibodyAnti-ZNF207 antibodyAnti-BUGZ antibody |
Information sourced from Uniprot.org