| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZNF207 |
| Gene ID: | 7756 |
| Uniprot ID: | ZN207_HUMAN |
| Immunogen Region: | 1-85 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-85 of human ZNF207 (NP_003448.1). |
| Immunogen Sequence: | MGRKKKKQLKPWCWYCNRDF DDEKILIQHQKAKHFKCHIC HKKLYTGPGLAIHCMQVHKE TIDAVPNAIPGRTDIELEIY GMEGI |
| Tissue Specificity | Ubiquitous. |
| Function | Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome. |
| Protein Name | Bub3-Interacting And Glebs Motif-Containing Protein Znf207 Bugz Hbugz Zinc Finger Protein 207 |
| Cellular Localisation | Nucleus Chromosome Centromere Kinetochore Cytoplasm Cytoskeleton Spindle Localizes Primarily To The Nucleus In Interphase Concentrates At Kinetochores Prior To Nuclear Envelope Breakdown And During Early Prometaphase And Disappears From Kinetochores Upon Microtubule-Binding |
| Alternative Antibody Names | Anti-Bub3-Interacting And Glebs Motif-Containing Protein Znf207 antibody Anti-Bugz antibody Anti-Hbugz antibody Anti-Zinc Finger Protein 207 antibody Anti-ZNF207 antibody Anti-BUGZ antibody |
Information sourced from Uniprot.org