Anti-ZNF131 antibody (80-240) (STJ117526)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ZNF131 (80-240) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZNF131 |
| Gene ID | 7690 |
| Uniprot ID | ZN131_HUMAN |
| Immunogen Region | 80-240 |
| Immunogen Sequence | MAFRHLIEFTYTAKLMIQGE EEANDVWKAAEFLQMLEAIK ALEVRNKENSAPLEENTTGK NEAKKRKIAETSNVITESLP SAESEPVEIEVEIAEGTIEV EDEGIETLEEVASAKQSVKY IQSTGSSDDSALALLADITS KYRQGDRKGQIKEDGCPSDP T |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 80-240 of human ZNF131 (NP_003423.1). |
Additional Info
| Tissue Specificity | Predominant expression is found in different brain areas such as the occipital and temporal lobe, the nucleus caudatus, hippocampus, and the cerebellum as well as in testis and thymus. |
| Post Translational Modifications | Monosumoylated at Lys-601 by CBX4 and UHRF2. Sumoylation may potentiate ZNF131 inhibition of estrogen signaling. Sumoylation does not interfere with ubiquitination. Ubiquitinated. |
| Function | Plays a role during development and organogenesis as well as in the function of the adult central nervous system. May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. |
| Protein Name | Zinc Finger Protein 131 |
| Database Links | Reactome: R-HSA-3899300 |
| Cellular Localisation | NucleusSumoylation Does Not Affect Nuclear Localization |
| Alternative Antibody Names | Anti-Zinc Finger Protein 131 antibodyAnti-ZNF131 antibody |
Information sourced from Uniprot.org