| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZNF131 (80-240) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZNF131 |
| Gene ID: |
7690 |
| Uniprot ID: |
ZN131_HUMAN |
| Immunogen Region: |
80-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 80-240 of human ZNF131 (NP_003423.1). |
| Immunogen Sequence: |
MAFRHLIEFTYTAKLMIQGE EEANDVWKAAEFLQMLEAIK ALEVRNKENSAPLEENTTGK NEAKKRKIAETSNVITESLP SAESEPVEIEVEIAEGTIEV EDEGIETLEEVASAKQSVKY IQSTGSSDDSALALLADITS KYRQGDRKGQIKEDGCPSDP T |
| Tissue Specificity | Predominant expression is found in different brain areas such as the occipital and temporal lobe, the nucleus caudatus, hippocampus, and the cerebellum as well as in testis and thymus. |
| Post Translational Modifications | Monosumoylated at Lys-601 by CBX4 and UHRF2. Sumoylation may potentiate ZNF131 inhibition of estrogen signaling. Sumoylation does not interfere with ubiquitination. Ubiquitinated. |
| Function | Plays a role during development and organogenesis as well as in the function of the adult central nervous system. May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. |
| Protein Name | Zinc Finger Protein 131 |
| Database Links | Reactome: R-HSA-3899300 |
| Cellular Localisation | NucleusSumoylation Does Not Affect Nuclear Localization |
| Alternative Antibody Names | Anti-Zinc Finger Protein 131 antibodyAnti-ZNF131 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
