| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZNF131 |
| Gene ID: | 7690 |
| Uniprot ID: | ZN131_HUMAN |
| Immunogen Region: | 80-240 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-240 of human ZNF131 (NP_003423.1). |
| Immunogen Sequence: | MAFRHLIEFTYTAKLMIQGE EEANDVWKAAEFLQMLEAIK ALEVRNKENSAPLEENTTGK NEAKKRKIAETSNVITESLP SAESEPVEIEVEIAEGTIEV EDEGIETLEEVASAKQSVKY IQSTGSSDDSALALLADITS KYRQGDRKGQIKEDGCPSDP T |
| Tissue Specificity | Predominant expression is found in different brain areas such as the occipital and temporal lobe, the nucleus caudatus, hippocampus, and the cerebellum as well as in testis and thymus. |
| Post Translational Modifications | Monosumoylated at Lys-601 by CBX4 and UHRF2. Sumoylation may potentiate ZNF131 inhibition of estrogen signaling. Sumoylation does not interfere with ubiquitination. Ubiquitinated. |
| Function | Plays a role during development and organogenesis as well as in the function of the adult central nervous system. May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. |
| Protein Name | Zinc Finger Protein 131 |
| Database Links | Reactome: R-HSA-3899300 |
| Cellular Localisation | NucleusSumoylation Does Not Affect Nuclear Localization |
| Alternative Antibody Names | Anti-Zinc Finger Protein 131 antibodyAnti-ZNF131 antibody |
Information sourced from Uniprot.org
