| Post Translational Modifications | Sumoylated following its interaction with PIAS1 and UBE2I. Ubiquitinated, leading to proteasomal degradation. |
| Function | Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction. |
| Protein Name | Zinc Finger Mynd Domain-Containing Protein 11Adenovirus 5 E1a-Binding ProteinBone Morphogenetic Protein Receptor-Associated Molecule 1Protein Bs69 |
| Cellular Localisation | NucleusChromosomeAssociates With Chromatin And Mitotic Chromosomes |
| Alternative Antibody Names | Anti-Zinc Finger Mynd Domain-Containing Protein 11 antibodyAnti-Adenovirus 5 E1a-Binding Protein antibodyAnti-Bone Morphogenetic Protein Receptor-Associated Molecule 1 antibodyAnti-Protein Bs69 antibodyAnti-ZMYND11 antibodyAnti-BRAM1 antibodyAnti-BS69 antibody |
Information sourced from Uniprot.org
