| Host: | Rabbit |
| Applications: | IHC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Zinc Finger Protein With Krab And Scan Domains 3 is suitable for use in Immunohistochemistry and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Purification: | Antigen affinity purification |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:40-1:250 |
| Storage Instruction: | Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: | ZKSCAN3 |
| Gene ID: | 80317 |
| Uniprot ID: | ZKSC3_HUMAN |
| Immunogen: | Fusion protein of human ZKSCAN3 |
| Function | Transcriptional factor that binds to the consensus sequence 5'-GTAGAGTGGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas. |
| Protein Name | Zinc Finger Protein With Krab And Scan Domains 3 Zinc Finger And Scan Domain-Containing Protein 13 Zinc Finger Protein 306 Zinc Finger Protein 309 Zinc Finger Protein 47 Homolog Zf47 Zfp-47 |
| Database Links | Reactome: R-HSA-212436 |
| Cellular Localisation | Nucleus Cytoplasm Mainly Localizes In The Nucleus Under Starvation Conditions Translocates To The Cytoplasm Allowing Expression Of Target Genes Involved In Autophagy And Lysosome Biogenesis/Function |
| Alternative Antibody Names | Anti-Zinc Finger Protein With Krab And Scan Domains 3 antibody Anti-Zinc Finger And Scan Domain-Containing Protein 13 antibody Anti-Zinc Finger Protein 306 antibody Anti-Zinc Finger Protein 309 antibody Anti-Zinc Finger Protein 47 Homolog antibody Anti-Zf47 antibody Anti-Zfp-47 antibody Anti-ZKSCAN3 antibody Anti-ZFP47 antibody Anti-ZNF306 antibody Anti-ZNF309 antibody Anti-ZSCAN13 antibody |
Information sourced from Uniprot.org