Anti-ZFYVE19 antibody (311-360 aa) (STJ96307)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human ZFYVE19 at the amino acid range 311-360
General Information
| Short Description | Rabbit polyclonal anti-Abscission/NoCut checkpoint regulator (311-360 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZFYVE19 |
| Gene ID | 84936 |
| Uniprot ID | ANCHR_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human ZFYVE19 at the amino acid range 311-360 |
| Immunogen Region | 311-360 aa |
| Specificity | ZFYVE19 Polyclonal Antibody detects endogenous levels of ZFYVE19 protein. |
Additional Info
| Post Translational Modifications | Phosphorylated in vitro at Ser-22 by AURKB.however, phosphorylation at this site could not be confirmed in vivo. |
| Function | Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. |
| Protein Name | Abscission/Nocut Checkpoint RegulatorAnchrMll Partner Containing Fyve DomainZinc Finger Fyve Domain-Containing Protein 19 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCleavage FurrowMidbodyMidbody RingLocalizes Mainly On Centrosomes In Interphase And Early MitosisLocalizes At The Cleavage Furrow And Midbody Ring In Late Mitosis And Cytokinesis |
| Alternative Antibody Names | Anti-Abscission/Nocut Checkpoint Regulator antibodyAnti-Anchr antibodyAnti-Mll Partner Containing Fyve Domain antibodyAnti-Zinc Finger Fyve Domain-Containing Protein 19 antibodyAnti-ZFYVE19 antibodyAnti-ANCHR antibodyAnti-MPFYVE antibody |
Information sourced from Uniprot.org