Anti-YEATS4 antibody (1-227) (STJ28240)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal YEATS4 (1-227) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | YEATS4 |
| Gene ID | 8089 |
| Uniprot ID | YETS4_HUMAN |
| Immunogen Region | 1-227 |
| Immunogen Sequence | MFKRMAEFGPDSGGRVKGVT IVKPIVYGNVARYFGKKREE DGHTHQWTVYVKPYRNEDMS AYVKKIQFKLHESYGNPLRV VTKPPYEITETGWGEFEIII KIFFIDPNERPVTLYHLLKL FQSDTNAMLGKKTVVSEFYD EMIFQDPTAMMQQLLTTSRQ LTLGAYKHETEFAELEVKTR EKLEAAKKKTSFEIAELKER LKASRETINCLKNEIRKLEE DDQAKDI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-227 of human YEATS4 (NP_006521.1). |
Additional Info
| Tissue Specificity | Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. |
| Function | Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac). Also able to recognize and bind crotonylated histone H3. May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ).additional evidences are however required to confirm this result in vivo. Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z. H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell. |
| Protein Name | Yeats Domain-Containing Protein 4Glioma-Amplified Sequence 41Gas41Numa-Binding Protein 1Nubi-1Nubi1 |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-8866907 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Yeats Domain-Containing Protein 4 antibodyAnti-Glioma-Amplified Sequence 41 antibodyAnti-Gas41 antibodyAnti-Numa-Binding Protein 1 antibodyAnti-Nubi-1 antibodyAnti-Nubi1 antibodyAnti-YEATS4 antibodyAnti-GAS41 antibody |
Information sourced from Uniprot.org