Anti-XPF antibody [ZN20] (STJA0033309)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
ImmunogenFull length human recombinant protein of human XPF (NP_005227) produced in HEK293 cell.
General Information
| Short Description | Mouse monoclonal anti-XPF for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | ZN20 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 0.5-1.0 mg/mL |
| Purification | Affinity Chromatography |
| Dilution Range | IHC 1:50-1:100 |
| Formulation | PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | ERCC4 |
| Gene ID | 2072 |
| Uniprot ID | XPF_HUMAN |
| Immunogen | Full length human recombinant protein of human XPF (NP_005227) produced in HEK293 cell. |
Additional Info
| Post Translational Modifications | Acetylation at Lys-911 by KAT5 promotes interaction with ERCC1 by disrupting a salt bridge between Glu-907 and Lys-911, thereby exposing a second binding site for ERCC1. Deacetylated by SIRT1. |
| Function | Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair. |
| Protein Name | Dna Repair Endonuclease XpfDna Excision Repair Protein Ercc-4Dna Repair Protein Complementing Xp-F CellsXeroderma Pigmentosum Group F-Complementing Protein |
| Database Links | Reactome: R-HSA-5685938Reactome: R-HSA-5696395Reactome: R-HSA-5696400Reactome: R-HSA-6782135Reactome: R-HSA-6783310 |
| Cellular Localisation | NucleusChromosomeLocalizes To Sites Of Dna Damage |
| Alternative Antibody Names | Anti-Dna Repair Endonuclease Xpf antibodyAnti-Dna Excision Repair Protein Ercc-4 antibodyAnti-Dna Repair Protein Complementing Xp-F Cells antibodyAnti-Xeroderma Pigmentosum Group F-Complementing Protein antibodyAnti-ERCC4 antibodyAnti-ERCC11 antibodyAnti-XPF antibody |
Information sourced from Uniprot.org