| Post Translational Modifications | Acetylation at Lys-911 by KAT5 promotes interaction with ERCC1 by disrupting a salt bridge between Glu-907 and Lys-911, thereby exposing a second binding site for ERCC1. Deacetylated by SIRT1. |
| Function | Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair. |
| Protein Name | Dna Repair Endonuclease XpfDna Excision Repair Protein Ercc-4Dna Repair Protein Complementing Xp-F CellsXeroderma Pigmentosum Group F-Complementing Protein |
| Database Links | Reactome: R-HSA-5685938Reactome: R-HSA-5696395Reactome: R-HSA-5696400Reactome: R-HSA-6782135Reactome: R-HSA-6783310 |
| Cellular Localisation | NucleusChromosomeLocalizes To Sites Of Dna Damage |
| Alternative Antibody Names | Anti-Dna Repair Endonuclease Xpf antibodyAnti-Dna Excision Repair Protein Ercc-4 antibodyAnti-Dna Repair Protein Complementing Xp-F Cells antibodyAnti-Xeroderma Pigmentosum Group F-Complementing Protein antibodyAnti-ERCC4 antibodyAnti-ERCC11 antibodyAnti-XPF antibody |
Information sourced from Uniprot.org
