| Short Description : | Rabbit polyclonal XDH (1066-1084) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | XDH |
| Gene ID: | 7498 |
| Uniprot ID: | XDH_HUMAN |
| Immunogen Region: | 1066-1084 |
| Immunogen Sequence: | VDKFNKENCWKKRGLCIIPT KFGISFTVPFLNQAGALLHV YTDGSVLLTHGGTEMGQGLH TKMVQVASRALKIPTSKIYI SETSTNTVPNTSPTAASVSA DLNGQAVYAACQTILKRLEP YKKKNPSGSWEDWVTAAYMD TVSLSATGFYRTPNLGYSFE TNSGNPFHYFSYGVACSEVE IDCLTGDHKNLRTDIVMDVG SSLNPAIDIGQVEGAFVQGL GLFTLEELHYSPEGSLHTR |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 985-1084 of human Xanthine Oxidase (XDH) (NP_000370.2). |
| Tissue Specificity | Detected in milk (at protein level). |
| Post Translational Modifications | Subject to partial proteolysis.this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O). Contains sulfhydryl groups that are easily oxidized (in vitro).this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O). |
| Function | Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). |
| Protein Name | Xanthine Dehydrogenase/Oxidase Includes - Xanthine DehydrogenaseXd - Xanthine OxidaseXoXanthine OxidoreductaseXor |
| Database Links | Reactome: R-HSA-74259Reactome: R-HSA-8851680Reactome: R-HSA-9748787 |
| Cellular Localisation | CytoplasmPeroxisomeSecreted |
| Alternative Antibody Names | Anti-Xanthine Dehydrogenase/Oxidase Includes - Xanthine Dehydrogenase antibodyAnti-Xd - Xanthine Oxidase antibodyAnti-Xo antibodyAnti-Xanthine Oxidoreductase antibodyAnti-Xor antibodyAnti-XDH antibodyAnti-XDHA antibody |
Information sourced from Uniprot.org
