Anti-WEE2 antibody (60-110) (STJ503524)

SKU:
STJ503524-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-WEE2 (60-110) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:2, 500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
IHC: 1:50-1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Wee2
Gene ID: 381759
Uniprot ID: WEE2_MOUSE
Immunogen Region: 60-110
Immunogen: Synthetic peptide taken within amino acid region 60-110 on mouse Wee1-like protein kinase isoform 2.
Post Translational Modifications Phosphorylated by PKA at Ser-15 in vitro, leading to activate kinase activity. Phosphorylation at Ser-15 by CaMK2, leading to increase its activity and promote metaphase II exit during egg activation.
Function Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.
Protein Name Wee1-Like Protein Kinase 2
Wee1-Like Protein Kinase 1b
Wee1b Kinase
Mwee1b
Cellular Localisation Cytoplasm
Nucleus
Localizes Mainly In The Nucleus
Exported From The Nucleus To The Cytoplasm Before Germinal Vesicle Breakdown (Gvbd)
Allowing Meiosis Resumption
Alternative Antibody Names Anti-Wee1-Like Protein Kinase 2 antibody
Anti-Wee1-Like Protein Kinase 1b antibody
Anti-Wee1b Kinase antibody
Anti-Mwee1b antibody
Anti-Wee2 antibody
Anti-Wee1b antibody

Information sourced from Uniprot.org

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