| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-WDR5 (1-334) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
WDR5 |
| Gene ID: |
11091 |
| Uniprot ID: |
WDR5_HUMAN |
| Immunogen Region: |
1-334 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-334 of human WDR5 (NP_438172.1). |
| Immunogen Sequence: |
MATEEKKPETEAARAQPTPS SSATQSKPTPVKPNYALKFT LAGHTKAVSSVKFSPNGEWL ASSSADKLIKIWGAYDGKFE KTISGHKLGISDVAWSSDSN LLVSASDDKTLKIWDVSSGK CLKTLKGHSNYVFCCNFNPQ SNLIVSGSFDESVRIWDVKT GKCLKTLPAHSDPVSAVHFN RDGSLIVSSSYDGLCRIWDT ASGQCLKTLIDDDNPPVSFV KFSPNGKYILAATLDNTLK |
| Function | Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation. In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B. |
| Protein Name | Wd Repeat-Containing Protein 5Bmp2-Induced 3-Kb Gene Protein |
| Database Links | Reactome: R-HSA-3214841Reactome: R-HSA-3214847Reactome: R-HSA-3214858Reactome: R-HSA-5617472Reactome: R-HSA-8936459Reactome: R-HSA-8951664Reactome: R-HSA-9733709Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Wd Repeat-Containing Protein 5 antibodyAnti-Bmp2-Induced 3-Kb Gene Protein antibodyAnti-WDR5 antibodyAnti-BIG3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
