Anti-WDR5 antibody (1-334) (STJ115543)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal WDR5 (1-334) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | WDR5 |
| Gene ID | 11091 |
| Uniprot ID | WDR5_HUMAN |
| Immunogen Region | 1-334 |
| Immunogen Sequence | MATEEKKPETEAARAQPTPS SSATQSKPTPVKPNYALKFT LAGHTKAVSSVKFSPNGEWL ASSSADKLIKIWGAYDGKFE KTISGHKLGISDVAWSSDSN LLVSASDDKTLKIWDVSSGK CLKTLKGHSNYVFCCNFNPQ SNLIVSGSFDESVRIWDVKT GKCLKTLPAHSDPVSAVHFN RDGSLIVSSSYDGLCRIWDT ASGQCLKTLIDDDNPPVSFV KFSPNGKYILAATLDNTLK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-334 of human WDR5 (NP_438172.1). |
Additional Info
| Function | Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation. In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B. |
| Protein Name | Wd Repeat-Containing Protein 5Bmp2-Induced 3-Kb Gene Protein |
| Database Links | Reactome: R-HSA-3214841Reactome: R-HSA-3214847Reactome: R-HSA-3214858Reactome: R-HSA-5617472Reactome: R-HSA-8936459Reactome: R-HSA-8951664Reactome: R-HSA-9733709Reactome: R-HSA-9772755Reactome: R-HSA-9818564Reactome: R-HSA-9841922 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Wd Repeat-Containing Protein 5 antibodyAnti-Bmp2-Induced 3-Kb Gene Protein antibodyAnti-WDR5 antibodyAnti-BIG3 antibody |
Information sourced from Uniprot.org