• Immunohistochemistry analysis of paraffin-embedded mouse kidney using KIAA1429 Rabbit polyclonal antibody (STJ118641) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using KIAA1429 Rabbit polyclonal antibody (STJ118641) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Western blot analysis of extracts of Mouse lung, using KIAA1429 antibody (STJ118641) at 1:2000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-VIRMA antibody (1400-1700) (STJ118641)

SKU:
STJ118641

£169.50 - £449.50
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Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-KIAA1429 (1400-1700) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:5000
IHC-P 1:50-1:200
IF/ICC 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: VIRMA
Gene ID: 25962
Uniprot ID: VIR_HUMAN
Immunogen Region: 1400-1700
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1400-1700 of human KIAA1429 (NP_056311.2).
Immunogen Sequence: FMRQILNSDTIGCCGDDNGL MEVEGAHTSRTMSINAAELK QLLQSKEESPENLFLELEKL VLEHSKDDDNLDSLLDSVVG LKQMLESSGDPLPLSDQDVE PVLSAPESLQNLFNNRTAYV LADVMDDQLKSMWFTPFQAE EIDTDLDLVKVDLIELSEKC CSDFDLHSELERSFLSEPSS PGRTKTTKGFKLGKHKHETF ITSSGKSEYIEPAKRAHVVP PPRGRGRGGFGQGIRPHDI
Function Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA).
Protein Name Protein Virilizer Homolog
Cellular Localisation Nucleus Speckle
Nucleus
Nucleoplasm
Cytoplasm
Mainly Nuclear With Some Fraction Located In The Cytoplasm
Zc3h13 Is Required To Anchor Component Of The Macom Subcomplex
Such As Virma
In The Nucleus
Alternative Antibody Names Anti-Protein Virilizer Homolog antibody
Anti-VIRMA antibody
Anti-KIAA1429 antibody
Anti-MSTP054 antibody

Information sourced from Uniprot.org

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