| Function | Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Functions in DNA double-strand break repair also by mediating the deubiquitination and subsequent stabilization of DGCR8, leading to the recruitment of DGCR8 binding partners to double strand breaks such as RNF168 or MDC1. In addition, promotes the deubiquitination and stabilization of the transcriptional repressor ZEB1. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 51Deubiquitinating Enzyme 51Ubiquitin Thioesterase 51Ubiquitin-Specific-Processing Protease 51 |
| Database Links | |
| Cellular Localisation | ChromosomeUpon Dna DamageChromatin-Bound Usp51 Disassociates From Chromatin Immediately Following Dna Damage And Reassociates With Chromatin Following Dna Repair |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 51 antibodyAnti-Deubiquitinating Enzyme 51 antibodyAnti-Ubiquitin Thioesterase 51 antibodyAnti-Ubiquitin-Specific-Processing Protease 51 antibodyAnti-USP51 antibody |
Information sourced from Uniprot.org
