| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Ubiquitin carboxyl-terminal hydrolase 51 is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
USP51 |
| Gene ID: |
158880 |
| Uniprot ID: |
UBP51_HUMAN |
| Specificity: |
UBP51 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Function | Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 51Deubiquitinating Enzyme 51Ubiquitin Thioesterase 51Ubiquitin-Specific-Processing Protease 51 |
| Cellular Localisation | ChromosomeUpon Dna DamageChromatin-Bound Usp51 Disassociates From Chromatin Immediately Following Dna Damage And Reassociates With Chromatin Following Dna Repair |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 51 antibodyAnti-Deubiquitinating Enzyme 51 antibodyAnti-Ubiquitin Thioesterase 51 antibodyAnti-Ubiquitin-Specific-Processing Protease 51 antibodyAnti-USP51 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
