| Tissue Specificity | Expressed in skeletal muscle, pancreas, liver and kidney. |
| Post Translational Modifications | Ubiquitinated by parkin (PRKN) at Lys-235 and Lys-289, leading to its degradation. |
| Function | Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65'. Acts as a negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 30Deubiquitinating Enzyme 30Ubiquitin Thioesterase 30Ubiquitin-Specific-Processing Protease 30Ub-Specific Protease 30 |
| Database Links | Reactome: R-HSA-5689880Reactome: R-HSA-9664873 |
| Cellular Localisation | Mitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 30 antibodyAnti-Deubiquitinating Enzyme 30 antibodyAnti-Ubiquitin Thioesterase 30 antibodyAnti-Ubiquitin-Specific-Processing Protease 30 antibodyAnti-Ub-Specific Protease 30 antibodyAnti-USP30 antibody |
Information sourced from Uniprot.org
