| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-USP18 (44-372) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
USP18 |
| Gene ID: |
11274 |
| Uniprot ID: |
UBP18_HUMAN |
| Immunogen Region: |
44-372 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 44-372 of human USP18 (NP_059110.2). |
| Immunogen Sequence: |
RPRAWDYPHGLVGLHNIGQ |
| Function | Interferon-induced ISG15-specific protease that plays a crucial role for maintaining a proper balance of ISG15-conjugated proteins in cells. Regulates protein ISGylation by efficiently cleaving ISG15 conjugates linked via isopeptide bonds. Regulates T-cell activation and T-helper 17 (Th17) cell differentiation by deubiquitinating TAK1, likely to keep TAK1-TAB complexes in steady conditions. In turn, restricts activation of NF-kappa-B, NFAT, and JNK as well as expression of IL2 in T-cells after TCR activation. Acts as a molecular adapter with USP20 to promote innate antiviral response through deubiquitinating STING1. Involved also in the negative regulation of the inflammatory response triggered by type I interferon. Upon recruitment by STAT2 to the type I interferon receptor subunit IFNAR2 interferes with the assembly of the ternary interferon-IFNAR1-IFNAR2 complex and acts as a negative regulator of the type I interferon signaling pathway. Isoform 2: Has enzymatic activity similar to isoform 1 and interferes with type I interferon signaling. Major deISGylation enzyme for nuclear proteins. |
| Protein Name | Ubl Carboxyl-Terminal Hydrolase 1843 Kda Isg15-Specific ProteaseHubp43Isg15-Specific-Processing ProteaseUbl Thioesterase 18 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-445989Reactome: R-HSA-5689880Reactome: R-HSA-912694Reactome: R-HSA-9758274 |
| Cellular Localisation | Isoform 1: CytoplasmIsoform 2: NucleusCytoplasm |
| Alternative Antibody Names | Anti-Ubl Carboxyl-Terminal Hydrolase 18 antibodyAnti-43 Kda Isg15-Specific Protease antibodyAnti-Hubp43 antibodyAnti-Isg15-Specific-Processing Protease antibodyAnti-Ubl Thioesterase 18 antibodyAnti-USP18 antibodyAnti-ISG43 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
