| Function | Interferon-induced ISG15-specific protease that plays a crucial role for maintaining a proper balance of ISG15-conjugated proteins in cells. Regulates protein ISGylation by efficiently cleaving ISG15 conjugates linked via isopeptide bonds. Regulates T-cell activation and T-helper 17 (Th17) cell differentiation by deubiquitinating TAK1, likely to keep TAK1-TAB complexes in steady conditions. In turn, restricts activation of NF-kappa-B, NFAT, and JNK as well as expression of IL2 in T-cells after TCR activation. Acts as a molecular adapter with USP20 to promote innate antiviral response through deubiquitinating STING1. Involved also in the negative regulation of the inflammatory response triggered by type I interferon. Upon recruitment by STAT2 to the type I interferon receptor subunit IFNAR2 interferes with the assembly of the ternary interferon-IFNAR1-IFNAR2 complex and acts as a negative regulator of the type I interferon signaling pathway. Isoform 2: Has enzymatic activity similar to isoform 1 and interferes with type I interferon signaling. Major deISGylation enzyme for nuclear proteins. |
| Protein Name | Ubl Carboxyl-Terminal Hydrolase 1843 Kda Isg15-Specific ProteaseHubp43Isg15-Specific-Processing ProteaseUbl Thioesterase 18 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-445989Reactome: R-HSA-5689880Reactome: R-HSA-912694Reactome: R-HSA-9758274 |
| Cellular Localisation | Isoform 1: CytoplasmIsoform 2: NucleusCytoplasm |
| Alternative Antibody Names | Anti-Ubl Carboxyl-Terminal Hydrolase 18 antibodyAnti-43 Kda Isg15-Specific Protease antibodyAnti-Hubp43 antibodyAnti-Isg15-Specific-Processing Protease antibodyAnti-Ubl Thioesterase 18 antibodyAnti-USP18 antibodyAnti-ISG43 antibody |
Information sourced from Uniprot.org
