| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UCHL5 |
| Gene ID: | 51377 |
| Uniprot ID: | UCHL5_HUMAN |
| Immunogen Region: | 1-328 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-328 of human UCHL5 (NP_001186190.1). |
| Immunogen Sequence: | MTGNAGEWCLMESDPGVFTE LIKGFGCRGAQVEEIWSLEP ENFEKLKPVHGLIFLFKWQP GEEPAGSVVQDSRLDTIFFA KQVINNACATQAIVSVLLNC THQDVHLGETLSEFKEFSQS FDAAMKGLALSNSDVIRQVH NSFARQQMFEFDTKTSAKEE DAFHFVSYVPVNGRLYELDG LREGPIDLGACNQDDWISAV RPVIEKRIQKYSEGEIRFNL MAIVSDRKMIYEQKIAELQ |
| Function | Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex.however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L5 Uch-L5 Ubiquitin C-Terminal Hydrolase Uch37 Ubiquitin Thioesterase L5 |
| Database Links | Reactome: R-HSA-2173788 Reactome: R-HSA-5689603 |
| Cellular Localisation | Cytoplasm Nucleus Associates With The Proteasome 19s Subunit In The Cytoplasm Associates With The Ino80 Complex In The Nucleus |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L5 antibody Anti-Uch-L5 antibody Anti-Ubiquitin C-Terminal Hydrolase Uch37 antibody Anti-Ubiquitin Thioesterase L5 antibody Anti-UCHL5 antibody Anti-UCH37 antibody Anti-AD-019 antibody Anti-CGI-70 antibody |
Information sourced from Uniprot.org