Anti-UBXN6 antibody (STJA0007234)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human UBXD1
General Information
| Short Description | Rabbit polyclonal anti-UBX domain-containing protein 6 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UBXN6 |
| Gene ID | 80700 |
| Uniprot ID | UBXN6_HUMAN |
| Immunogen | Synthesized peptide derived from human UBXD1 |
| Specificity | This antibody detects endogenous levels of UBXD1 at Human, Mouse |
Additional Info
| Function | May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. |
| Protein Name | Ubx Domain-Containing Protein 6Ubx Domain-Containing Protein 1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytosolMembranePeripheral Membrane ProteinNucleusCytoskeletonMicrotubule Organizing CenterCentrosomeEarly Endosome MembraneLate Endosome MembraneLysosome MembraneLocalizes At The Centrosome Both In Interphase And During MitosisMay Be Recruited To Endosomal And Lysosomal Membranes As Part Of A Ternary Complex With Cav1 And VcpRecruited To Damaged Lysosomes Decorated With K48-Linked Ubiquitin Chains |
| Alternative Antibody Names | Anti-Ubx Domain-Containing Protein 6 antibodyAnti-Ubx Domain-Containing Protein 1 antibodyAnti-UBXN6 antibodyAnti-UBXD1 antibodyAnti-UBXDC2 antibody |
Information sourced from Uniprot.org