| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-UBX domain-containing protein 6 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UBXN6 |
| Gene ID: |
80700 |
| Uniprot ID: |
UBXN6_HUMAN |
| Specificity: |
This antibody detects endogenous levels of UBXD1 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human UBXD1 |
| Function | May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. |
| Protein Name | Ubx Domain-Containing Protein 6Ubx Domain-Containing Protein 1 |
| Cellular Localisation | CytoplasmCytosolMembranePeripheral Membrane ProteinNucleusCytoskeletonMicrotubule Organizing CenterCentrosomeEarly Endosome MembraneLate Endosome MembraneLysosome MembraneLocalizes At The Centrosome Both In Interphase And During MitosisMay Be Recruited To Endosomal And Lysosomal Membranes As Part Of A Ternary Complex With Cav1 And VcpRecruited To Damaged Lysosomes Decorated With K48-Linked Ubiquitin Chains |
| Alternative Antibody Names | Anti-Ubx Domain-Containing Protein 6 antibodyAnti-Ubx Domain-Containing Protein 1 antibodyAnti-UBXN6 antibodyAnti-UBXD1 antibodyAnti-UBXDC2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
