Anti-UBE4B antibody (1-100) [S0MR] (STJ11102680)

Name: Anti-UBE4B antibody (1-100) [S0MR] (STJ11102680)
SKU: STJ11102680
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11102680

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Short Description	Rabbit monoclonal UBE4B (1-100) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	S0MR
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	UBE4B
Gene ID	10277
Uniprot ID	UBE4B_HUMAN
Immunogen Region	1-100
Immunogen Sequence	MEELSADEIRRRRLARLAGG QTSQPTTPLTSPQRENPPGP PIAASAPGPSQSLGLNVHNM TPATSPIGASGVAHRSQSSE GVSSLSSSPSNSLETQSQSL
Specificity	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UBE4B (O95155).

Tissue Specificity	Expressed in differentiated myotubes (at protein level). Highest expression in ovary, testis, heart and skeletal muscle. Expression is low in colon, thymus and peripheral blood leukocytes. Almost undetectable in lung and spleen.
Post Translational Modifications	Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B. Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-7.
Function	Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation.
Protein Name	Ubiquitin Conjugation Factor E4 B Homozygously Deleted In Neuroblastoma 1 Ring-Type E3 Ubiquitin Transferase E4 B Ubiquitin Fusion Degradation Protein 2
Database Links
Cellular Localisation	Cytoplasm Nucleus
Alternative Antibody Names	Anti-Ubiquitin Conjugation Factor E4 B antibody Anti-Homozygously Deleted In Neuroblastoma 1 antibody Anti-Ring-Type E3 Ubiquitin Transferase E4 B antibody Anti-Ubiquitin Fusion Degradation Protein 2 antibody Anti-UBE4B antibody Anti-HDNB1 antibody Anti-KIAA0684 antibody Anti-UFD2 antibody

Information sourced from Uniprot.org