• Anti-UACA antibody [AE-5] (STJ16101008)

Anti-UACA antibody [AE-5] (STJ16101008)

SKU:
STJ16101008

£264.50 - £1,251.50
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Host: Mouse
Applications: FC/WB/IF/IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-UACA is suitable for use in Flow Cytometry, Western Blot, Immunofluorescence and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: AE-5
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: PBS with 0.02% Sodium Azide.
Purification: Affinity purified from tissue culture.
Concentration: Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL.
Dilution Range: Flow Cytometry (1-2 µg/million cells in 0, 1 ml, fix cells in 4% PFA for 10 min, at 4°C, permeabilize with 0, 2% saponin or digitonin for 15 min, at 4°C). Immunoblotting (1-2 µg/ml). Immunofluorescence (0, 5-1, 0 µg/ml).Immunohistology (1-2 µg/ml for
Storage Instruction: Store for up to 1 year at 2-8°C upon receipt.
Gene Symbol: UACA
Gene ID: 55075
Uniprot ID: UACA_HUMAN
Immunogen: A BALB/c mouse was immunized with nuclei of myeloid leukemia biopsy cells. Fusion partner: NS-1.
Tissue Specificity Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells.
Function Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1. Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation.
Protein Name Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats
Database Links Reactome: R-HSA-9013407
Reactome: R-HSA-9627069
Cellular Localisation Nucleus
Cytoplasm
Cytoskeleton
Expressed Diffusely In Cytoplasm
Alternative Antibody Names Anti-Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats antibody
Anti-UACA antibody
Anti-KIAA1561 antibody

Information sourced from Uniprot.org

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