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![Anti-UACA antibody [AE-5] (STJ16101008)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149724/302465/STJ16101008_1__59898.1646940649.jpg?c=1 "Anti-UACA antibody [AE-5] (STJ16101008)")
Anti-UACA antibody [AE-5] (STJ16101008)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenA BALB/c mouse was immunized with nuclei of myeloid leukemia biopsy cells. Fusion partner: NS-1.
General Information
| Short Description | Mouse monoclonal anti-UACA for use in FC, WB, IF and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/WB/IF/IHC |
| Host | Mouse |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AE-5 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL. |
| Purification | Affinity purified from tissue culture. |
| Dilution Range | Flow Cytometry (1-2 µg/million cells in 0, 1 ml, fix cells in 4% PFA for 10 min, at 4°C, permeabilize with 0, 2% saponin or digitonin for 15 min, at 4°C). Immunoblotting (1-2 µg/ml). Immunofluorescence (0, 5-1, 0 µg/ml).Immunohistology (1-2 µg/ml for |
| Formulation | PBS with 0.02% Sodium Azide. |
| Storage Instruction | Store for up to 1 year at 2-8°C upon receipt. |
Target Information
| Gene Symbol | UACA |
| Gene ID | 55075 |
| Uniprot ID | UACA_HUMAN |
| Immunogen | A BALB/c mouse was immunized with nuclei of myeloid leukemia biopsy cells. Fusion partner: NS-1. |
Additional Info
| Tissue Specificity | Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells. |
| Function | Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1. Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation. |
| Protein Name | Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats |
| Database Links | Reactome: R-HSA-9013407Reactome: R-HSA-9627069 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonExpressed Diffusely In Cytoplasm |
| Alternative Antibody Names | Anti-Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats antibodyAnti-UACA antibodyAnti-KIAA1561 antibody |
Information sourced from Uniprot.org