Anti-UACA antibody [AE-5] (STJ16101008)

Anti-UACA antibody [AE-5] (STJ16101008)

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STJ16101008
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Short Description :Mouse monoclonal anti-UACA for use in FC, WB, IF and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications:FC/WB/IF/IHC
Host:Mouse
Reactivity:Human/Mouse
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :AE-5
Isotype:IgG1k
Conjugation:Unconjugated
Concentration:Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL.
Purification:Affinity purified from tissue culture.
Dilution Range:Flow Cytometry (1-2 µg/million cells in 0, 1 ml, fix cells in 4% PFA for 10 min, at 4°C, permeabilize with 0, 2% saponin or digitonin for 15 min, at 4°C). Immunoblotting (1-2 µg/ml). Immunofluorescence (0, 5-1, 0 µg/ml).Immunohistology (1-2 µg/ml for
Formulation:PBS with 0.02% Sodium Azide.
Storage Instruction:Store for up to 1 year at 2-8°C upon receipt.
Gene Symbol:UACA
Gene ID:55075
Uniprot ID:UACA_HUMAN
Immunogen:A BALB/c mouse was immunized with nuclei of myeloid leukemia biopsy cells. Fusion partner: NS-1.
Tissue Specificity Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells.
Function Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1. Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation.
Protein Name Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats
Database Links Reactome: R-HSA-9013407
Reactome: R-HSA-9627069
Cellular Localisation Nucleus
Cytoplasm
Cytoskeleton
Expressed Diffusely In Cytoplasm
Alternative Antibody Names Anti-Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats antibody
Anti-UACA antibody
Anti-KIAA1561 antibody

Information sourced from Uniprot.org

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