| Host: |
Mouse |
| Applications: |
IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Tyrosinase (250-350 aa) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
ABT242 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1k |
| Formulation: |
Liquid in PBS pH7.2, 0.03% Proclin 300, with stabilizing protein. |
| Purification: |
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: |
IHC-P 1:200-400 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TYR |
| Gene ID: |
7299 |
| Uniprot ID: |
TYRO_HUMAN |
| Immunogen Region: |
250-350 aa |
| Specificity: |
The antibody can specifically recognize human Tyrosinase protein.. The antibody was also Predict react with Mouse;Rat |
| Immunogen: |
Synthesized peptide derived from the human Tyrosinase at the amino acid range 250-350 |
| Function | This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. |
| Protein Name | TyrosinaseLb24-AbMonophenol MonooxygenaseSk29-AbTumor Rejection Antigen Ab |
| Database Links | Reactome: R-HSA-5662702 |
| Cellular Localisation | Melanosome MembraneSingle-Pass Type I Membrane ProteinMelanosomeProper Trafficking To Melanosome Is Regulated By Sgsm2Ankrd27Rab9aRab32 And Rab38 |
| Alternative Antibody Names | Anti-Tyrosinase antibodyAnti-Lb24-Ab antibodyAnti-Monophenol Monooxygenase antibodyAnti-Sk29-Ab antibodyAnti-Tumor Rejection Antigen Ab antibodyAnti-TYR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
