Anti-TYR antibody (250-350 aa) [ABT242] (STJ197248)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenSynthesized peptide derived from the human Tyrosinase at the amino acid range 250-350
General Information
| Short Description | Mouse monoclonal anti-Tyrosinase (250-350 aa) for use in IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | ABT242 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range | IHC-P 1:200-400 |
| Formulation | Liquid in PBS pH7.2, 0.03% Proclin 300, with stabilizing protein. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TYR |
| Gene ID | 7299 |
| Uniprot ID | TYRO_HUMAN |
| Immunogen | Synthesized peptide derived from the human Tyrosinase at the amino acid range 250-350 |
| Immunogen Region | 250-350 aa |
| Specificity | The antibody can specifically recognize human Tyrosinase protein.. The antibody was also Predict react with Mouse;Rat |
Additional Info
| Function | This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. |
| Protein Name | TyrosinaseLb24-AbMonophenol MonooxygenaseSk29-AbTumor Rejection Antigen Ab |
| Database Links | Reactome: R-HSA-5662702Reactome: R-HSA-9824585 |
| Cellular Localisation | Melanosome MembraneSingle-Pass Type I Membrane ProteinMelanosomeProper Trafficking To Melanosome Is Regulated By Sgsm2Ankrd27Rab9aRab32 And Rab38 |
| Alternative Antibody Names | Anti-Tyrosinase antibodyAnti-Lb24-Ab antibodyAnti-Monophenol Monooxygenase antibodyAnti-Sk29-Ab antibodyAnti-Tumor Rejection Antigen Ab antibodyAnti-TYR antibody |
Information sourced from Uniprot.org