| Short Description : | Rabbit polyclonal Twinfilin-2 (1-349) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TWF2 |
| Gene ID: | 11344 |
| Uniprot ID: | TWF2_HUMAN |
| Immunogen Region: | 1-349 |
| Immunogen Sequence: | MAHQTGIHATEELKEFFAKA RAGSVRLIKVVIEDEQLVLG ASQEPVGRWDQDYDRAVLPL LDAQQPCYLLYRLDSQNAQG FEWLFLAWSPDNSPVRLKML YAATRATVKKEFGGGHIKDE LFGTVKDDLSFAGYQKHLSS CAAPAPLTSAERELQQIRIN EVKTEISVESKHQTLQGLAF PLQPEAQRALQQLKQKMVNY IQMKLDLERETIELVHTEPT DVAQLPSRVPRDAARYHFF |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-349 of human TWF2 (NP_009215.1). |
| Tissue Specificity | Ubiquitously expressed (at protein level). |
| Post Translational Modifications | In vitro, phosphorylated by PRKCZ, CK2 and SRC. |
| Function | Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia. |
| Protein Name | Twinfilin-2A6-Related ProteinHa6rpProtein Tyrosine Kinase 9-LikeTwinfilin-1-Like Protein |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | CytoplasmCytoskeletonPerinuclear RegionCell ProjectionStereociliumPerinuclear And G-Actin-Rich Cortical Actin Structure Sublocalization |
| Alternative Antibody Names | Anti-Twinfilin-2 antibodyAnti-A6-Related Protein antibodyAnti-Ha6rp antibodyAnti-Protein Tyrosine Kinase 9-Like antibodyAnti-Twinfilin-1-Like Protein antibodyAnti-TWF2 antibodyAnti-PTK9L antibodyAnti-MSTP011 antibody |
Information sourced from Uniprot.org
