Anti-TWF2 antibody (1-349 aa) [SRM5376] (STJ11107287)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal TWF2 (1-349 aa) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5376 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:10000-1:20000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
Target Information
| Gene Symbol | TWF2 |
| Gene ID | 11344 |
| Uniprot ID | TWF2_HUMAN |
| Immunogen Region | 1-349 aa |
| Immunogen Sequence | MAHQTGIHATEELKEFFAKA RAGSVRLIKVVIEDEQLVLG ASQEPVGRWDQDYDRAVLPL LDAQQPCYLLYRLDSQNAQG FEWLFLAWSPDNSPVRLKML YAATRATVKKEFGGGHIKDE LFGTVKDDLSFAGYQKHLSS CAAPAPLTSAERELQQIRIN EVKTEISVESKHQTLQGLAF PLQPEAQRALQQLKQKMVNY IQMKLDLERETIELVHTEPT DVAQLPSRVPRDAARYHFF |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-349 of human TWF2 (NP_009215.1). |
Additional Info
| Tissue Specificity | Ubiquitously expressed (at protein level). |
| Post Translational Modifications | In vitro, phosphorylated by PRKCZ, CK2 and SRC. |
| Function | Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia. |
| Protein Name | Twinfilin-2A6-Related ProteinHa6rpProtein Tyrosine Kinase 9-LikeTwinfilin-1-Like Protein |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | CytoplasmCytoskeletonPerinuclear RegionCell ProjectionStereociliumPerinuclear And G-Actin-Rich Cortical Actin Structure Sublocalization |
| Alternative Antibody Names | Anti-Twinfilin-2 antibodyAnti-A6-Related Protein antibodyAnti-Ha6rp antibodyAnti-Protein Tyrosine Kinase 9-Like antibodyAnti-Twinfilin-1-Like Protein antibodyAnti-TWF2 antibodyAnti-PTK9L antibodyAnti-MSTP011 antibody |
Information sourced from Uniprot.org