Anti-TUSC3/N33 antibody (Internal) (STJ71488)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-TUSC3/N33 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:1000.WB: Approx 37kDa band observed in Human Liver and Lung lysates (calculated MW of 39.7kDa according to NP_006756.2 and of 39.6 according to NP_839952.1). An additional band of unknown identi |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | TUSC3 |
| Gene ID | 7991 |
| Uniprot ID | TUSC3_HUMAN |
| Accession Number | NP_006756.2; NP_839952.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | PQRQCSVCRQAN |
| Specificity | This antibody is expected to recognise both reported isoforms (NP_006756.2; NP_839952.1). |
Additional Info
| Function | Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues.in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. Could indirectly play a role in Mg(2+) transport. |
| Protein Name | Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Tusc3Oligosaccharyl Transferase Subunit Tusc3Magnesium Uptake/Transporter Tusc3Protein N33Tumor Suppressor Candidate 3 |
| Database Links | Reactome: R-HSA-446203Reactome: R-HSA-5223345Reactome: R-HSA-9694548 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Tusc3 antibodyAnti-Oligosaccharyl Transferase Subunit Tusc3 antibodyAnti-Magnesium Uptake/Transporter Tusc3 antibodyAnti-Protein N33 antibodyAnti-Tumor Suppressor Candidate 3 antibodyAnti-TUSC3 antibodyAnti-N33 antibody |
Information sourced from Uniprot.org