• Immunofluorescence analysis of U-2 OS cells using TTF1 Rabbit polyclonal antibody (STJ11100098) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.

Anti-TTF1 antibody (806-905) (STJ11100098)

SKU:
STJ11100098

£169.50 - £449.50
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Host: Rabbit
Applications: IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TTF1 (806-905) is suitable for use in Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TTF1
Gene ID: 7270
Uniprot ID: TTF1_HUMAN
Immunogen Region: 806-905
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 806-905 of human TTF1 (NP_031370.2).
Immunogen Sequence: RLKAVYVPFWQKKTFPEIID YLYETTLPLLKEKLEKMMEK KGTKIQTPAAPKQVFPFRDI FYYEDDSEGEDIEKESEGQA PCMAHACNSSTLGGQGRWII
Function Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.
Protein Name Transcription Termination Factor 1
Ttf-1
Rna Polymerase I Termination Factor
Transcription Termination Factor I
Ttf-I
Database Links Reactome: R-HSA-427389
Reactome: R-HSA-427413
Reactome: R-HSA-5683826
Reactome: R-HSA-73762
Reactome: R-HSA-73863
Cellular Localisation Nucleus
Nucleolus
Nucleoplasm
May Be Localized To The Nucleolus In An Npm1/B23-Dependent Manner
May Be Displaced From The Nucleolus Into The Nucleoplasm In An Cdkn2a/Arf-Dependent Manner
May Shuttle Back And Forth From Nucleoplasm To Nucleolus
Alternative Antibody Names Anti-Transcription Termination Factor 1 antibody
Anti-Ttf-1 antibody
Anti-Rna Polymerase I Termination Factor antibody
Anti-Transcription Termination Factor I antibody
Anti-Ttf-I antibody
Anti-TTF1 antibody

Information sourced from Uniprot.org

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