Anti-TTF1 antibody (806-905) (STJ11100098)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TTF1 (806-905) antibody for use in IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TTF1 |
| Gene ID | 7270 |
| Uniprot ID | TTF1_HUMAN |
| Immunogen Region | 806-905 |
| Immunogen Sequence | RLKAVYVPFWQKKTFPEIID YLYETTLPLLKEKLEKMMEK KGTKIQTPAAPKQVFPFRDI FYYEDDSEGEDIEKESEGQA PCMAHACNSSTLGGQGRWII |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 806-905 of human TTF1 (NP_031370.2). |
Additional Info
| Function | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. |
| Protein Name | Transcription Termination Factor 1Ttf-1Rna Polymerase I Termination FactorTranscription Termination Factor ITtf-I |
| Database Links | Reactome: R-HSA-427389Reactome: R-HSA-427413Reactome: R-HSA-5683826Reactome: R-HSA-73762Reactome: R-HSA-73863 |
| Cellular Localisation | NucleusNucleolusNucleoplasmMay Be Localized To The Nucleolus In An Npm1/B23-Dependent MannerMay Be Displaced From The Nucleolus Into The Nucleoplasm In An Cdkn2a/Arf-Dependent MannerMay Shuttle Back And Forth From Nucleoplasm To Nucleolus |
| Alternative Antibody Names | Anti-Transcription Termination Factor 1 antibodyAnti-Ttf-1 antibodyAnti-Rna Polymerase I Termination Factor antibodyAnti-Transcription Termination Factor I antibodyAnti-Ttf-I antibodyAnti-TTF1 antibody |
Information sourced from Uniprot.org