Confocal imaging of paraffin-embedded Human thyroid using NKX2-1 Rabbit monoclonal antibody (STJ11103513, dilution 1:200) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (dilution 1:500) (Red). DAPI was used for nuclear staining (Blue). Objective: 40x. Perform high pressure antigen retrieval with 0. 01 M citRate buffer (pH 6. 0) prior to IF staining.

Anti-TTF1 antibody (1-100) [S3MR] (STJ11103513)

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STJ11103513
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Host: Rabbit
Applications: WB/IHC-P/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : S3MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:1000-1:6000
IHC-P:1:500-1:2000
IF/ICC:1:200-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NKX2-1
Gene ID: 7080
Uniprot ID: NKX21_HUMAN
Immunogen Region: 1-100
Specificity: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NKX2-1 (P43699).
Immunogen Sequence: MSMSPKHTTPFSVSDILSPL EESYKKVGMEGGGLGAPLAA YRQGQAAPPTAAMQQHAVGH HGAVTAAYHMTAAGVPQLSH SAVGGYCNGNLGNMSELPPY
Tissue Specificity Thyroid and lung.
Post Translational Modifications Phosphorylated on serine residues by STK3/MST2.
Function Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1.
Protein Name Homeobox Protein Nkx-2.1
Homeobox Protein Nk-2 Homolog A
Thyroid Nuclear Factor 1
Thyroid Transcription Factor 1
Ttf-1
Thyroid-Specific Enhancer-Binding Protein
T/Ebp
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Homeobox Protein Nkx-2.1 antibody
Anti-Homeobox Protein Nk-2 Homolog A antibody
Anti-Thyroid Nuclear Factor 1 antibody
Anti-Thyroid Transcription Factor 1 antibody
Anti-Ttf-1 antibody
Anti-Thyroid-Specific Enhancer-Binding Protein antibody
Anti-T/Ebp antibody
Anti-NKX2-1 antibody
Anti-NKX2A antibody
Anti-TITF1 antibody
Anti-TTF1 antibody

Information sourced from Uniprot.org

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