Anti-TTF1 antibody (1-100) [S3MR] (STJ11103513)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal TTF1 (1-100) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S3MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:6000IHC-P:1:500-1:2000IF/ICC:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NKX2-1 |
| Gene ID | 7080 |
| Uniprot ID | NKX21_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MSMSPKHTTPFSVSDILSPL EESYKKVGMEGGGLGAPLAA YRQGQAAPPTAAMQQHAVGH HGAVTAAYHMTAAGVPQLSH SAVGGYCNGNLGNMSELPPY |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NKX2-1 (P43699). |
Additional Info
| Tissue Specificity | Thyroid and lung. |
| Post Translational Modifications | Phosphorylated on serine residues by STK3/MST2. |
| Function | Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1. |
| Protein Name | Homeobox Protein Nkx-2.1Homeobox Protein Nk-2 Homolog AThyroid Nuclear Factor 1Thyroid Transcription Factor 1Ttf-1Thyroid-Specific Enhancer-Binding ProteinT/Ebp |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Nkx-2.1 antibodyAnti-Homeobox Protein Nk-2 Homolog A antibodyAnti-Thyroid Nuclear Factor 1 antibodyAnti-Thyroid Transcription Factor 1 antibodyAnti-Ttf-1 antibodyAnti-Thyroid-Specific Enhancer-Binding Protein antibodyAnti-T/Ebp antibodyAnti-NKX2-1 antibodyAnti-NKX2A antibodyAnti-TITF1 antibodyAnti-TTF1 antibody |
Information sourced from Uniprot.org