| Short Description : | Rabbit polyclonal TSSK4 (79-328) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TSSK4 |
| Gene ID: | 283629 |
| Uniprot ID: | TSSK4_HUMAN |
| Immunogen Region: | 79-328 |
| Immunogen Sequence: | VLRHKYLINFYRAIESTSRV YIILELAQGGDVLEWIQRYG ACSEPLAGKWFSQLTLGIAY LHSKSIVHRDLKLENLLLDK WENVKISDFGFAKMVPSNQP VGCSPSYRQVNCFSHLSQTY CGSFAYACPEILRGLPYNPF LSDTWSMGVILYTLVVAHLP FDDTNLKKLLRETQKEVTFP ANHTISQECKNLILQMLRQA TKRATILDIIKDSWVLKFQP EQPTHEIRLLEAMCQLHNT |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 79-328 of human TSSK4 (NP_777604.2). |
| Tissue Specificity | Expressed only in the testis. |
| Post Translational Modifications | Activated by autophosphorylation on Thr-197. ODF2 potentiates the autophosphorylation activity of TSSK4 at Thr-197. Ubiquitinated.HSP90 activity negatively regulates ubiquitination and degradation. |
| Function | Serine/threonine kinase which is involved in male germ cell development and in mature sperm function. May be involved in the Cre/Creb signaling pathway. Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells. Phosphorylates CREM on 'Ser-116' in vitro. Phosphorylates ODF2 on 'Ser-95'. |
| Protein Name | Testis-Specific Serine/Threonine-Protein Kinase 4Tsk-4Tssk-4Testis-Specific Kinase 4Serine/Threonine-Protein Kinase 22e |
| Database Links | |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleAcrosomeCell ProjectionCiliumFlagellumIn SpermatozoaPresent In The Sperm Head And In The Flagellum |
| Alternative Antibody Names | Anti-Testis-Specific Serine/Threonine-Protein Kinase 4 antibodyAnti-Tsk-4 antibodyAnti-Tssk-4 antibodyAnti-Testis-Specific Kinase 4 antibodyAnti-Serine/Threonine-Protein Kinase 22e antibodyAnti-TSSK4 antibodyAnti-C14orf20 antibodyAnti-STK22E antibodyAnti-TSSK5 antibody |
Information sourced from Uniprot.org
