Anti-TBC1D21 antibody (278-328) (STJA0006472)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human TBC21 AA range: 278-328
General Information
| Short Description | Rabbit polyclonal anti-TBC1 domain family member 21 (278-328) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TBC1D21 |
| Gene ID | 161514 |
| Uniprot ID | TBC21_HUMAN |
| Immunogen | Synthesized peptide derived from human TBC21 AA range: 278-328 |
| Immunogen Region | 278-328 |
| Specificity | This antibody detects endogenous levels of human TBC21 |
Additional Info
| Function | Acts as a GTPase-activating protein for Rab family protein(s). Essential for the establishment of male fertility, and is required for both the production of normal sperm number and sperm function. Plays an important role in the formation of intact mitochondria, outer dense fibers and axoneme within the sperm tail. Essential for sperm mitochondrial sheath formation and for the interactions of ARMC12 with VDAC2 and VDAC3. May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity. |
| Protein Name | Tbc1 Domain Family Member 21Male Germ Cell Rab Gtpase-Activating Protein |
| Database Links | |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleAcrosomeCytoplasmCytoskeletonLocated At The Edge Of The Acrosomal RegionNeck And Annulus During SpermiogenesisColocalizes With Rab3a At The Acrosome-Acroplaxome And Neck Regions Of SpermatidsColocalizes With Actb At The Neck Region In Elongated Spermatids |
| Alternative Antibody Names | Anti-Tbc1 Domain Family Member 21 antibodyAnti-Male Germ Cell Rab Gtpase-Activating Protein antibodyAnti-TBC1D21 antibodyAnti-MGCRABGAP antibody |
Information sourced from Uniprot.org