Host: | Goat |
Applications: | Pep-ELISA/WB/ICC/IF |
Reactivity: | Human/Mouse/Rat/Dog/Pig/Cow |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Goat polyclonal antibody anti-TRPV5 (Internal) is suitable for use in ELISA, Western Blot, Immunocytochemistry and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: | 0.5 mg/mL |
Dilution Range: | WB-1-3µg/ml ELISA-antibody detection limit dilution 1:16000. |
Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Gene Symbol: | TRPV5 |
Gene ID: | 56302 |
Uniprot ID: | TRPV5_HUMAN |
Immunogen Region: | Internal |
Accession Number: | NP_062815.2 |
Immunogen Sequence: | SHRGWEILRQNT |
Post Translational Modifications | Glycosylated. |
Function | Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. |
Protein Name | Transient Receptor Potential Cation Channel Subfamily V Member 5 Trpv5 Calcium Transport Protein 2 Cat2 Epithelial Calcium Channel 1 Ecac Ecac1 Osm-9-Like Trp Channel 3 Otrpc3 |
Database Links | Reactome: R-HSA-3295583 |
Cellular Localisation | Apical Cell Membrane Multi-Pass Membrane Protein Colocalized With S100a10 And Anax2 Along The Apical Domain Of Kidney Distal Tubular Cells The Expression Of The Glycosylated Form In The Cell Membrane Is Increased In The Presence Of Wnk3 |
Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily V Member 5 antibody Anti-Trpv5 antibody Anti-Calcium Transport Protein 2 antibody Anti-Cat2 antibody Anti-Epithelial Calcium Channel 1 antibody Anti-Ecac antibody Anti-Ecac1 antibody Anti-Osm-9-Like Trp Channel 3 antibody Anti-Otrpc3 antibody Anti-TRPV5 antibody Anti-ECAC1 antibody |
Information sourced from Uniprot.org