| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRPM1 (1460-1540) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRPM1 |
| Gene ID: |
4308 |
| Uniprot ID: |
TRPM1_HUMAN |
| Immunogen Region: |
1460-1540 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1460-1540 of human TRPM1 (NP_002411.3). |
| Immunogen Sequence: |
SITDQQLTTEWQCQVQKITR SHSTDIPYIVSEAAVQAEHK EQFADMQDEHHVAEAIPRIP RLSLTITDRNGMENLLSVKP D |
| Tissue Specificity | Expressed in the retina where it localizes to the outer plexiform layer. Specifically, it is expressed in retinal bipolar cells (BPCs) of the ON subtype. Highly expressed in benign melanocytic nevi and diffusely expressed in various in situ melanomas, but not detected in melanoma metastases. Also expressed in melanocytes and pigmented metastatic melanoma cell lines. In melanocytes expression appears to be regulated at the level of transcription and mRNA processing. |
| Function | Forms nonselective divalent cation-conducting channels which mediate the influx of Na(2+), Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization. Impermeable to zinc ions. In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions. Essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression. May act as a spontaneously active, calcium-permeable plasma membrane channel. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily M Member 1Long Transient Receptor Potential Channel 1Ltrpc1Melastatin-1 |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneCell ProjectionAxon |
| Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily M Member 1 antibodyAnti-Long Transient Receptor Potential Channel 1 antibodyAnti-Ltrpc1 antibodyAnti-Melastatin-1 antibodyAnti-TRPM1 antibodyAnti-LTRPC1 antibodyAnti-MLSN antibodyAnti-MLSN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
