Anti-TRPC4AP antibody (STJA0007424)

SKU:
STJA0007424

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Short transient receptor potential channel 4-associated protein is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TRPC4AP
Gene ID: 26133
Uniprot ID: TP4AP_HUMAN
Specificity: This antibody detects endogenous levels of TRPC4AP at Human, Mouse
Immunogen: Synthesized peptide derived from human TRPC4AP
Function Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway. The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.
Protein Name Short Transient Receptor Potential Channel 4-Associated Protein
Trp4-Associated Protein
Trpc4-Associated Protein
Protein Tap1
Tnf-Receptor Ubiquitous Scaffolding/Signaling Protein
Protein Truss
Database Links Reactome: R-HSA-3295583
Cellular Localisation Cytoplasm
Perinuclear Region
Alternative Antibody Names Anti-Short Transient Receptor Potential Channel 4-Associated Protein antibody
Anti-Trp4-Associated Protein antibody
Anti-Trpc4-Associated Protein antibody
Anti-Protein Tap1 antibody
Anti-Tnf-Receptor Ubiquitous Scaffolding/Signaling Protein antibody
Anti-Protein Truss antibody
Anti-TRPC4AP antibody
Anti-C20orf188 antibody
Anti-TRRP4AP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance