Anti-TRPC4AP antibody (STJA0007424)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human TRPC4AP
General Information
| Short Description | Rabbit polyclonal anti-Short transient receptor potential channel 4-associated protein for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRPC4AP |
| Gene ID | 26133 |
| Uniprot ID | TP4AP_HUMAN |
| Immunogen | Synthesized peptide derived from human TRPC4AP |
| Specificity | This antibody detects endogenous levels of TRPC4AP at Human, Mouse |
Additional Info
| Function | Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway. The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1. |
| Protein Name | Short Transient Receptor Potential Channel 4-Associated ProteinTrp4-Associated ProteinTrpc4-Associated ProteinProtein Tap1Tnf-Receptor Ubiquitous Scaffolding/Signaling ProteinProtein Truss |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | CytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-Short Transient Receptor Potential Channel 4-Associated Protein antibodyAnti-Trp4-Associated Protein antibodyAnti-Trpc4-Associated Protein antibodyAnti-Protein Tap1 antibodyAnti-Tnf-Receptor Ubiquitous Scaffolding/Signaling Protein antibodyAnti-Protein Truss antibodyAnti-TRPC4AP antibodyAnti-C20orf188 antibodyAnti-TRRP4AP antibody |
Information sourced from Uniprot.org