| Short Description : | Rabbit polyclonal TRMT6 (1-200) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TRMT6 |
| Gene ID: | 51605 |
| Uniprot ID: | TRM6_HUMAN |
| Immunogen Region: | 1-200 |
| Immunogen Sequence: | MEGSGEQPGPQPQHPGDHRI RDGDFVVLKREDVFKAVQVQ RRKKVTFEKQWFYLDNVIGH SYGTAFEVTSGGSLQPKKKR EEPTAETKEAGTDNRNIVDD GKSQKLTQDDIKALKDKGIK GEEIVQQLIENSTTFRDKTE FAQDKYIKKKKKKYEAIITV VKPSTRILSIMYYAREPGKI NHMRYDTLAQMLTLGNIRAG |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human TRMT6 (NP_057023.2). |
| Tissue Specificity | Expressed in brain, liver, testis and ovary. |
| Function | Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries. |
| Protein Name | TrnaAdenine(58-N(1-Methyltransferase Non-Catalytic Subunit Trm6Mrna Methyladenosine-N(1-Methyltransferase Non-Catalytic Subunit Trm6Trna(M1a58-Methyltransferase Subunit Trm6Trna(M1a58mtase Subunit Trm6 |
| Database Links | Reactome: R-HSA-6782315 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Trna antibodyAnti-Adenine(58-N(1-Methyltransferase Non-Catalytic Subunit Trm6 antibodyAnti-Mrna Methyladenosine-N(1-Methyltransferase Non-Catalytic Subunit Trm6 antibodyAnti-Trna(M1a58-Methyltransferase Subunit Trm6 antibodyAnti-Trna(M1a58mtase Subunit Trm6 antibodyAnti-TRMT6 antibodyAnti-KIAA1153 antibodyAnti-TRM6 antibodyAnti-CGI-09 antibody |
Information sourced from Uniprot.org
